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brasiliensis infection, in vivo.To download a Parallels HALB appliance, visit The mRNA expression of mouse Eotaxin is not restricted to Th2 T cells in vitro and is independent of the development of a Th2-type response during N. Its mRNA levels parallel the kinetics of eosinophil accumulation in the lung during the experimentally induced eosinophilia and it is mainly produced by type I alveolar epithelial cells. The recombinant protein encoded by this gene displays potent and specific chemotactic activity for eosinophils, both in vivo and in vitro. We describe the identification and cloning of a cDNA that encodes a mouse C-C chemokine with 68% amino acid identity to guinea pig Eotaxin. brasiliensis infection, in vivo.ĪB - A model of lung eosinophilia based on the repeated exposure of mice to aerosolized OVA has been used to identify C-C chemokine genes expressed at stages of massive eosinophil infiltration. N2 - A model of lung eosinophilia based on the repeated exposure of mice to aerosolized OVA has been used to identify C-C chemokine genes expressed at stages of massive eosinophil infiltration. Potter fellow.Ĭopyright 2018 Elsevier B.V., All rights reserved. was a recipient of a World Health Organization training grant. G is a recipient of postdoctoral fellowship of the Spanish Ministry for Science. The Basel Institute for Immunology was funded and is supported by Hoffman-La Roche, Incorporated. This work has been funded in part by Leukosite, Incorporated, by National Institutes of Health grant HL 148675–02 and the Aplastic Foundation of America grants and National Cancer Institute, Department of Health and Human Services. Ponath, Bozza, de la Pompa, Van Etten, Payne, Williams, and Von Andrian for technical help and important suggestions. Cepko for use of her dissecting scope and camera. MacKay for his continuous support and interaction, which were integral for the complete development of this project, and Dr. Gerard for critical reading of this manuscript. Finger for excellent technical assistance and to Drs. T1 - Mouse Eotaxin expression parallels eosinophil accumulation during lung allergic inflammation but it is not restricted to a Th2-type response Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
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Note = "Funding Information: The authors are indebted to Mr.